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Review all 19 research articles from our Livestream Event: Gluten Sensitivity: Fantasy, Fad, Fiction or Fact?  

Read the full article Here.

Top Three Tips for Better Health

It can be a challenge to establish good health habits with today’s hectic lifestyle. And if you’re one of the millions living with a chronic condition, it can be even harder. Too often we neglect our health until a health crisis — such as celiac disease or gluten sensitivity — forces us to examine how we live and make some serious changes. The practices we develop in this space require time and effort, but the rewards are tremendous. Positive lifestyle changes can propel you to a healthier, happier place than you have ever known. Read More

News regarding Pediatric Autoimmune Disease:

Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study.

Abstract

Background: The significance of hypergammaglobulinemia as a marker of immune activation is unknown, as a differential diagnosis for hypergammaglobulinemia in children has not been adequately established. The goal of this study was to identify conditions associated with hypergammaglobulinemia in children, with the hypothesis that elevated immunoglobulin levels may precede or predict the development of autoimmune conditions.

Methods: We reviewed the medical records for all children with IgG level ≥2000 mg/dL treated at a tertiary care children’s hospital from January 1, 2000 through December 31, 2009. We compared clinical and laboratory features of these patients, and developed an algorithm to predict the likelihood of underlying autoimmunity based on these characteristics.

Results: After excluding children who had received IVIG, a total of 442 patients with hypergammaglobulinemia were identified. Of these, nearly half had autoimmune conditions, most frequently systemic lupus erythematosus and lupus-related disorders. Autoimmune gastrointestinal disorders such as inflammatory bowel disease were also common. Infectious diseases were the next largest category of diseases, followed with much less frequency by malignant, drug-related, and other conditions. In comparison with non-autoimmune conditions, patients with autoimmune disease had higher IgG levels, lower white blood cell counts, lower hemoglobin values, and lower C-reactive protein (CRP) levels. Multivariable logistic regression confirmed that CRP (P = 0.002), white blood cell count (P < 0.001), hemoglobin (P = 0.015), and female gender (P < 0.001) are independent risk factors for autoimmune disease in patients with high IgG levels.

Conclusions: In a cohort of pediatric patients at a tertiary care children’s hospital, hypergammaglobulinemia was most commonly associated with autoimmune diseases. In female patients with hypergammaglobulinemia, the presence of leukopenia, anemia, and normal CRP was 95% predictive of underlying autoimmune disease. You can read the Full Article Here.

Dr. Fasano on the future of celiac disease

What he thinks about the biopsy, a .pill, the economy, an Increase in CD … and GF pizza By Amy Ratner

SEVEN YEARS AGO, I sat down for an in-depth interview with Alessio Fasano, MD, director of the Center for Celiac Research, shortly after his landmark study that detennined one in 133 people has celiac disease. There was great excitement at that time about all the things likely to happen now that it was clear celiac disease was much more common than anyone thought. We met that time in his office at the University of Maryland School of Medicine in downtown Baltimore. It seemed fitting to be talking about the study and other cutting edge research not far from the celiac center clinic lab where much ofthe work was going on. This time we talked over lunch in a noisy pizza parlor that has gluten-free pizza on its menu-something we could only have dreamed about in 2003. Fasano, a prolific celiac researcher, writer, ambassador and advocate, had just returned from an ambitious trip to Europe where he traveled between Finland, Germany and his native Italy. In Finland, he donned a topcoat with tails and a very tall hat to participate in formal proceedings where a fellow researcher was defending his thesis on the role the biopsy plays in the diagnosis of celiac disease. Read More

Reintroduce Gluten : Gluten Sensitivity Testing

Question: Do I have to reintroduce gluten in order to have an accurate gluten sensitivity test done?

Answer: Yes and No Read More

Gluten Sensitivity: Real Disorder, Real Symptoms

There’s a lot of confusion about gluten sensitivity. Some say it doesn’t exist. Others think going gluten free without celiac disease is unnecessary and is just a fad. But science now confirms what glutensensitive patients and their doctors have known for years: Gluten sensitivity is a real disorder with defined symptoms that can affect any part of the body.  Read More

Predicting and Preventing Autoimmunity, Myth or Reality?

Taken as a group, autoimmune diseases are the third leading cause of morbidity and mortality in the industrialized world, only surpassed by cancer and heart disease. Many autoimmune diseases are chronic diseases that progress over the course of years and are characterized by the presence of autoantibodies that precede the overt disease. Autoantibodies may also predict specific clinical manifestation, disease severity, and rate of progression, as well as specific clinical phenomena, such as autoimmune pregnancy loss. Read More

 
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