Mediator Release Testing, MRT®, is a functional measurement of immunological pathways activated by food and food chemicals in the diet. It measures the inflammatory response and subtle changes in our immune cells (lymphocytes, neutrophils, monocytes, and eosinophils) as they release chemical mediators (a substance released from cells, e.g., cytokines, histamine, leukotrienes, prostaglandins, etc.), that regulate or cause physiologic consequences during an immune response to an antigen. It’s the release of these chemical mediators that leads to the negative clinical effects a person with a food sensitivity experiences.
The measurement of these chemical mediators is obtained after a food or food-chemical exposure and calculates these changes as either “non-reactive,” “moderately-reactive,” or “reactive,” based on the level of inflammation induced from the exposure. The immune mediator release, which brings about inflammation, is the key event that leads to negative symptoms.
Millions of Americans suffer from food sensitivities that can contribute to inflammation, pain and various symptoms that can drastically reduce their quality of life. Without question, food sensitivities and allergic reactions to foods and food chemicals are on the rise making diagnostic testing an important way to identify adverse immunological responses to various foods and chemicals. Traditional medical tests are often not able to identify sensitivities and only look for full blown allergic (IgE) responses.
Adverse immune reactions to foods contribute to chronic conditions such as autoimmune issues, IBS and IBD, rheumatoid arthritis, fibromyalgia, lupus, GERD or acid reflux, sinusitis, asthma, autism, ADD, etc. Research shows that the following symptoms can also be triggered by food sensitivities: weight gain or loss, anxiety, depression, brain fog, lack of focus and/or concentration, digestive disorders such as chronic diarrhea, migraines, joint and muscle pain, skin conditions, fatigue, insomnia, slow wound healing and an inability to recover effectively from exercise, etc.
It can take time for our immune system to respond and we may not feel the effects of a reactive food for up to 72 hours after ingestion. The fact that a person may not feel symptoms for hours, or even days, after ingestion, makes it more difficult for a connection to be made (e.g., a headache felt today and the pizza eaten two days ago). A specific food can elicit a very different response for each individual. A strawberry can cause a skin breakout for one person and not another. Any person can develop a sensitivity to any food, even foods considered to be nourishing and healthy. Sometimes a “reactive” food (e.g., dairy) can be easy to identify. Unfortunately, a chemical like solanine, found in nightshades like tomatoes, peppers, potatoes, eggplant and even spices, may not be so easy to pinpoint.
The adult MRT® panel consists of 123 foods and 27 food additives commonly found in the American diet. The single factor that all food sensitivities and all food-induced immune reactions have in common is the proinflammatory and proalgesic (related to or causing pain) mediator release from white cells. MRT® aims to measure the levels of inflammation. Additionally, there are seven different possible types of immune reactions to foods; meaning that a problematic food or food chemical can activate the immune system in one of seven different ways. MRT® accounts for all seven types of food sensitivity reactions. Even the most popular food sensitivity blood test available, the ELISA IgG, can only detect one out of the seven different types of reactions.
Research shows that:
- MRT® is able to distinguish between symptomatic and asymptomatic populations
- MRT® correlates with inflammation and symptoms
- Diets based on MRT® show significant symptom reduction
- MRT® has excellent real-world reproducibility
The LEAP Eating Plan is a personalized nutritional plan based on your MRT® results. Not only does MRT® give insight into inflammation provoking foods and food chemicals, but more importantly MRT® identifies your BEST foods – the foods that form the basis of your LEAP Eating Plan. Simply put, MRT® gives you information you can’t get any other way, and that information directly translates into a targeted nutrition plan that is personalized to meet your needs.
The goal of the LEAP Eating Plan is to address food sensitivities and help you achieve the maximum outcomes in the shortest period of time. For many people, following a personalized LEAP Eating Plan has shown significant symptom reduction.
In the past an elimination diet by trial and error was required to figure out which foods were causing symptoms. Fortunately, a LEAP Eating Plan can help you quickly overcome even the most troublesome food sensitivity related issues.
LEAP-150 Mediator Release Test (MRT®) - Food Sensitivity Screen Kit includes:
- Test kit mailed directly to you with pre-paid FedEx return mailer
- Detailed instructions for the blood draw
- Your Report of Findings outlining your test results
Steps involved in process:
- Blood draw for MRT® to be done at a nearby facility then shipped via FedEx overnight to Oxford Biomedical. Use this link to find a Phlebotomy Service in your area: http://nowleap.com/drawlocator/
- MRT® results and comprehensive diet guidelines are mailed to you.
Phlebotomy services are not included in the cost of this kit. Please contact the lab in your area directly for any associated draw fees.
*Your test includes a 30 minute Interpretation of your results with Michelle Ross, Director of Clinical Services.