COMPREHENSIVE DETOXIFICATION SUPPORT
GS DUAL-DETOX
by Dr. Tom O'Bryan
Promote balanced activity between Phase I and Phase II of the body’s detoxification processes. Avoid the dreaded “re-tox” symptoms.
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
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Promote balanced activity between Phase I and Phase II of the body’s detoxification processes.
Watch this video to learn more about both of our digestive enzymes
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
Effective Dual Phase Detoxification Process
Our Toxic Environment
Toxins are pervasive in today’s environment. Industrial and agricultural chemicals pollute our water and outdoor air, and it’s no better inside. Our carpets, cabinetry, mattresses, and furniture release harmful chemicals for years after they enter our homes, and the vast majority of cleaning and personal care products contain carcinogens and endocrine disruptors.
Unfortunately, many of these chemicals are fat-soluble, making them difficult to excrete because they adhere to fatty tissues.
The result can be toxins that linger in the body for years — causing fatigue, headaches, unexplained pain, mood disturbances, and hormonal imbalance.
The body is designed to rid itself of toxins through a complex two-phase detoxification process, but given the reality of modern environmental degradation, sometimes it needs a little help.
Unfortunately, many of these chemicals are fat-soluble, making them difficult to excrete because they adhere to fatty tissues.
The result can be toxins that linger in the body for years — causing fatigue, headaches, unexplained pain, mood disturbances, and hormonal imbalance.
The body is designed to rid itself of toxins through a complex two-phase detoxification process, but given the reality of modern environmental degradation, sometimes it needs a little help.
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS
ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
GS DUAL-DETOX
$45.95
GS Dual Detox is designed to promote balanced activity between Phase I and Phase II of the body’s detoxification processes.* It has been formulated to contain select ingredients to support healthy detoxification and enhance the activities of hepatic detoxification enzymes.
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS
ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
The Two Phases of Detoxification
The good news is that the body is equipped with a two-phase detoxification system to defuse and eliminate toxins; sometimes it just needs a little help. In Phase I, some chemicals are immediately neutralized. However, others are actually converted into more toxic intermediary forms before they are made water-soluble and eliminated in Phase II. Because toxins are oxidized during Phase I, harmful free radicals are also generated. If the body is more efficient at Phase I detoxification than Phase II, it may end up more overloaded with toxins than when it started. Therefore, it is important for any detoxifying dietary supplement to promote balanced activity between both phases.
GS Dual Detox Supports Both Phases of Detoxification
GS Dual-Detox includes a range of evidence-based Dual Phase Optimizers —substances that support both Phase I and Phase II detoxification:
- Vitamins B6, B12 and Folate, all necessary for methylation — a process whereby toxins are made water-soluble through the addition of a methyl group.*1
- The renowned herb milk thistle, whose active constituent silymarin stimulates both Phase I and Phase II detoxification enzymes.*2-3
- The antioxidant N-Acetyl L-Cysteine (NAC), which is so powerful, it is used in hospitals to counteract hepatotoxicity.*4-5
All of the included B vitamins are provided in their biologically active forms (vitamin B6 as pyridoxal-5’- phosphate, vitamin B12 as methylcobalamin, and Folate as Quatrefolic® 5-MTHF), allowing their unimpeded and rapid uptake into the bloodstream.
GS Dual-Detox features ingredients that work solely to enhance Phase II detoxification and support the excretion of toxins from the body.* For example, during the process of sulfation, toxins are neutralized through the addition of a sulfate. Therefore, sulfur-containing substances such as sodium sulfate, methylsulfonylmethane (MSM), and NAC are effective detoxifiers.*6 Ellagic acid (from pomegranate),7 Calcium D-Glucarate,8 watercress,9 alpha lipoic acid,10 and catechins from green tea leaf extract,11 also stimulate Phase II detoxification pathways.* Calcium D-Glucarate improves the metabolism of toxins due to its ability to increase glucuronidation.* Through this process, glucuronic acid is added to a substance, yielding compounds called glucuronides. These end products are more water-soluble than their parent compounds, facilitating their elimination from the body. Many xenobiotic substances — such as drugs, pollutants, and hormones — are processed through glucuronidation. Animal research indicates calcium d-glucarate protects tissues against excessive estrogen exposure through enhancing glucuronidation.
GS Dual-Detox features ingredients that work solely to enhance Phase II detoxification and support the excretion of toxins from the body.* For example, during the process of sulfation, toxins are neutralized through the addition of a sulfate. Therefore, sulfur-containing substances such as sodium sulfate, methylsulfonylmethane (MSM), and NAC are effective detoxifiers.*6 Ellagic acid (from pomegranate),7 Calcium D-Glucarate,8 watercress,9 alpha lipoic acid,10 and catechins from green tea leaf extract,11 also stimulate Phase II detoxification pathways.* Calcium D-Glucarate improves the metabolism of toxins due to its ability to increase glucuronidation.* Through this process, glucuronic acid is added to a substance, yielding compounds called glucuronides. These end products are more water-soluble than their parent compounds, facilitating their elimination from the body. Many xenobiotic substances — such as drugs, pollutants, and hormones — are processed through glucuronidation. Animal research indicates calcium d-glucarate protects tissues against excessive estrogen exposure through enhancing glucuronidation.
Finally, GS Dual-Detox incorporates antioxidants to help quench any free radicals released during the first phase of detoxification, such as artichoke leaf extract*12 and alphalipoic acid.*13 Artichoke also helps increase bile secretion and urine output, both of which enhance the excretion of toxins.*14
Extra Reinforcement for Phase II Detoxification*
Since free radicals can be released during Phase I detoxification, GS Dual-Detox includes critical antioxidants such as artichoke leaf and alpha-lipoic acid to help protect your body from oxidative stress and protect cellular integrity.*
Antioxidant Protection to Mop Up Free Radicals
Because Phase I detoxification can actually transform toxins into even more toxic intermediary forms, GS Dual Detox also features ingredients that work solely to enhance this critical Phase II detoxification process.* These include sodium sulfate, MSM, and ellagic acid which help eliminate or greatly reduce the symptoms of toxic overload.*
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS
ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
Why Use GS DUAL-DETOX?
GS Dual-Detox is designed to promote balanced activity between Phase I and Phase II of the body’s detoxification processes.* It has been formulated to contain select ingredients to support healthy detoxification and enhance the activities of hepatic detoxification enzymes.* GS Dual-Detox includes a range of evidence-based Dual Phase Optimizers —substances that support both Phase I and Phase II detoxification. The term Dual Phase Optimizers (DPO) refers to those nutrients that have the ability to simultaneously influence and “optimize” the activity of certain Phase I enzymes as well as Phase II enzymes. By balancing and promoting these hepatoprotective properties these substances can favorably influence toxin metabolism and elimination.* The 5-MTHF in this formula –Quatrefolic® – is the most biologically active form of folate, allowing rapid uptake into the bloodstream.* The 5-MTHF in this formula is also known as the “L” form of 5-MTHF since it is the reduced form of folate.
*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THESE PRODUCTS ARE NOT INTENDED
TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE
TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE
References
- Hall DC. Nutritional influences on estrogen metabolism. Applied Nutritional Science Reports. 2001. http://www.lucieblouin/PDF/EstrogenMetabANSR. pdf
- Silybummarianum (milk thistle). Alternative Medicine Review. 1999;4(4):272-274.
- Yanaida Y, et al. Carcinogenesis. 2002 May;23(5):787-94.
- Baniasadi S, et al. Eur J Gastroenterol Hepatol. Oct 2010;22(10):1235-1238.
- Yarema MC, Johnson DW, Berlin RJ, et al. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med. Oct 2009;54(4):606-614.
- Lord RS, Bralley JA. Clinical applications of urinary organic acids. Part 1: Detoxification markers. Alternative Medicine Review. 2008 Sep;13(3):205-15.
- Liska DJ. The detoxification enzyme system. Alternative Medicine Review. 1998;3(3):187-98.
- Lord RS, Bralley JA. 2008.
- Rose P, et al. 7-Methylsulfinylheptyl and 8-methylsulfinylocytl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000 Nov;21(11):1983-8.
- Ki SH, Kim SG. Phase II enzyme induction by alpha-lipoic acid through phosphatidylinositol 3-kinase-dependent C/EBPs activation. Xenobiotica 2008 Jun;38(6):587-604.
- Gates D. Studies show tea’s important detoxification properties. Body Ecology. 2009 May http://bodyecology/articles/studies-show-tea-detoxifi cation. php#.Ui4SeEYsxEd
- Armanu E, et al. Tropical Journal of Pharmaceutical Research 2011 Dec;10(6):777-83.
- Ki SH, Kim SG. 2008.
- Vamanu E, et al. 2011
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