BPA Plastic and Brain Development

Bisphenol A, more commonly known as BPA, is a chemical that helps to shape plastic, but when it comes to shaping brain development, it may be setting you up for brain dysfunction.

As I put together materials for my Brain Masterclass and wrote my best-selling book You Can Fix Your Brain: Just 1 Hour a Week to the Best Memory, Productivity, and Sleep You’ve Ever Had, BPA was a toxin that I could not ignore.

BPA has a cumulative effect. One of the problems is that BPA is one of the most highly produced chemicals in the world. It is a known xenoestrogen (Great scrabble word!). It means it is a hormone disruptor that mimics estrogen by binding to estrogen receptor sites in your body. This means your body receives BPA thinking it is estrogen, except instead it is a toxic chemical weakening your body’s ability to function properly. This includes BPA’s interference with brain development during critical stages of your life.

We’ve crossed a threshold of toxic chemicals. It used to be that we would test to see if you had BPA in your urine. It’s a waste of time and a waste of money to do that anymore. Everybody has BPA in their urine now. Infants are born with BPA in their bloodstream because they got it from their mother.

Let me repeat that; infants are born with BPA in their bloodstream.

That’s the frightening reality we live in. Babies are being born with toxic burden — or at least well on their way to it. So rather than waste time and money checking to see if it is in their urine, we now skip straight to checking to see if they are pumping out antibodies to BPA, meaning they’ve crossed the line, and their immune system will not tolerate it anymore. That’s when their immune system is trying to fight BPA. 

In other words, upon entry into this world, your child may already be on the autoimmune spectrum, primed for a litany of diseases. It’s not exactly the dream any of us wish for our children.

Up until recently, we poured fuel on the fire with baby bottles and sippy cups made with BPA. As parents began to hear whispers of BPA not being good for their children, industry shifted out of sheer demand.

What was all the fuss about? BPA carries an increased risk on a baby’s brain development that could lead to long-term effects. This endocrine disruptor was also linked to an increased risk of cancer, diabetes, and obesity, just to mention a few. The concerns were not new. Awareness was.


Unsuspecting mothers were inadvertently increasing the amounts of BPA their children got by heating up baby bottles. How much? Up to 55-fold! As BPA plastic came in contact with hot, boiling water or formula, the BPA chemical leached out into the liquid. Innocent babies everywhere then ingested BPA, putting them at risk for impaired brain development.

These concerns led to bans in BPA use in baby bottles (and sippy cups) in the United States (2012), Malaysia (2012), Europe (2011), Canada (2008), China (2011), and South Africa (2011). Those warm bottles of formula intended to nourish tiny minds were potentially having a cumulative negative effect on their brain development, as well as other areas of their health.

While this substance is off the list for baby bottles in many areas now, it can still be found in the tupperware you store (and perhaps heat) your food in, the toys your toddler plays with and puts in their mouth, and the lining of water pipes that you use every day. Over time, this can potentially impact your brain development.

As the consumer began to associate the term “BPA” as negative, the free market created it’s sisters of destruction: BPS and BPF. So the safety of the BPA-free label may not imply it is any safer than its previous plastic. 

Exposing Your Child to BPA May Harm Their Brain Development

Exposure to BPA at an early age appears to put a child at risk both for long-term diseases later in life as well as crippling healthy development of their brain at a critical stage. 

A recent study reported that BPA may suppress genes necessary in the early development of a child’s nervous system, setting them up for neurodevelopmental disorders. In other words, BPA negatively impacts brain development. 

Dana C. Dolinoy from Durham, North Carolina conducted a study The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. 

Epigenetics is defined as the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. In terms of nature vs nurture, epigenetics is nurture. Genetics is nature. 

We cannot change the genetic codes that we are born with. Epigenetics are the triggers that cause the genetic codes to be expressed or not expressed. A common expression used to describe this is “genetics load the gun; epigenetics pulls the trigger.”

In a study, they fed BPA to pregnant mice and examined the neurons in the brains of their offspring. The baby mice who were exposed to BPA had changes in how their genetic coding was expressed. It influenced the DNA methylation in the brain neurons.  In other words, BPA interfered with their brain development.

Dana C. Dolinoy cites in her study that “Throughout the years, the definition of epigenetics has evolved, while the number of molecular phenomena involving epigenetic pathways has grown. Recently, yet another metaphor was put forward to describe the field of epigenetics as a ‘bridge between genotype and phenotype’ that alters gene expression without changing the underlying DNA sequence. The notion that early environmental exposures interact with epigenetic gene regulation to influence phenotype and adult disease suggests that epigenetic gene regulation serves as a link between nature and nurture.”(1) 

This is what we witnessed in exposing developing fetuses of mice to BPA.

Brain Development Problems Seen From BPA Use

Here are a few ways you may see your brain development impacted:

  • Behavioral Problems – In addition to heart disease, reproductive disorders, and obesity, higher levels of BPA in urine are associated with hyperactivity, behavioral problems, and ADHD.

  • Disruption of Neural Circuits – BPA inhibits KCC2 from lowering chloride levels in the brain. KCC2 transports chloride from the brain; however, if chloride levels are too high, the connections between the neurons and synapses don’t form or connect properly.

  • Anxiety and Depression – BPA is an endocrine disruptor. Prenatal exposure to high levels of BPA is associated with anxiety and depression at a young age, specifically in boys. To learn how anxiety and depression can also be a result of poor gut health, see my blog Depression and Anxiety May Be Linked to Your Gut Health.

As I mentioned earlier, BPA is one of the most commonly used chemicals produced worldwide. Avoiding BPA is one of many steps you can take to protect your brain health at every age. Some of the places BPA lurks may just surprise you.

You can find BPA in these common places:

  • Plastic bottles
  • Water bottles
  • Tupperware
  • Sports equipment
  • CDs and DVDs
  • Food and beverage cans
  • Sales receipts
  • Medical equipment

Swapping out BPA Plastic for Better Brain Health

Remember when I talked about genetics and epigenetics? Epigenetics was pulling the trigger of a loaded gun. This puts the power in your hands — prevention is your best friend.

Let me be crystal clear about this: Genetics do not imply that an autoimmune condition is your destiny. You are born with those genes you carry for life. They may never be triggered and get “expressed.” And there is no shortage to the plethora of diseases you could get — but you don’t.

It’s the lifestyle choices, the toxins, the EMFs, the repeated exposures to foods we are sensitive to, and heavy metals that ignite certain gene expressions that lead to autommune conditions. This is great news because that means that we have a lot of control over whether we ever get an autoimmune condition in the first place.

As I detail in my Brain Masterclass, you can reduce toxic burdens (like BPA exposure), clean up your environment, remove heavy metals from your system, reduce EMF (Electromagnetic Frequency) exposure from devices like microwaves, cell phones, and wireless devices in order to minimize your risk of triggering those bad genes. 

For those of you who are healthy, it allows you to maintain optimal health. For those of you who are already on the autoimmune spectrum, reigning this in can be a game changer for symptoms. So let’s look at some simple ways you can reduce our BPA exposure and protect your brain health.

Be mindful (of your brain) when making these purchases.

  • Coffee lids — When you get that travel cup of coffee to go, that plastic lid on top of your coffee is being heated by the warmth of your hot beverage. Then, that condensation drips back down into your drink, taking with it the BPA that the heat leached out. Remove the lid.

  • Water bottles — Help yourself and the environment, and use a reusable water bottle. You can simply use a glass bottle, but if you prefer something that won’t break, opt for a stainless steel water bottle that does not contain any plastic lining on the inside.

  • Fruits and vegetables — Purchase whole foods in the produce or freezer aisle. Avoid canned foods.

  • Tupperware, pitchers, and cups — Swap out your plastic kitchenware for glass, porcelain or stainless steel containers for hot foods and liquids. And NEVER heat your food in plastic containers. Just get rid of them.

  • Toys — Purchase organic toys made from natural products — Dolls don’t need to be plastic.

It’s all about making a simple paradigm shift when you purchase items.

Over the years, I have found that people seeking good health get overwhelmed at the number of improvements they need to make in their lives. You don’t have to kill yourself trying to get better. You don’t have to do everything today.

That’s why I called my book You Can Fix Your Brain: Just 1 Hour a Week to the Best Memory, Productivity, and Sleep You’ve Ever Had. It’s not meant to be a cute title. It’s meant to be a tool to get you out of the pool of autoimmunity and into a safe harbor that you can create. It’s time to draw a line in the sand and get the strategies that optimize your brain’s health.

Every week take one hour to make a simple change in your environment; throw out the plastic tupperware and get a set of glass storage containers. If every week you do one thing, imagine the cleaner environment you are creating. The beauty of it is that your safe space that supports your health also will support the health of others that enter it.

It is possible to unlock your brain’s potential. Get in-depth information and action steps you can implement immediately when you enroll in my Brain Masterclass or pick up a copy of my best selling book, You Can Fix Your Brain.

(1) Dolinoy DC. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev. 2008;66 Suppl 1(Suppl 1):S7–S11. doi:10.1111/j.1753-4887.2008.00056.x

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American Ginseng, a revered herb, is prized for its potential to contribute to overall well-being. With adaptogenic properties, it may assist the body in managing stress and maintaining harmony. American Ginseng has also been associated with promoting mental alertness, healthy energy levels, and supporting the immune system.

Rhodiola Rosea

Rhodiola Rosea, a robust herb, is admired for its potential to support overall wellness. As an adaptogen, Rhodiola Rosea may help the body cope with stress and maintain balance. This remarkable herb has been linked to promoting mental clarity, healthy energy levels, and increased endurance.

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Peruvian Maca, a nutrient-packed root, is celebrated for its potential to enhance overall well-being. Known for its adaptogenic qualities, Maca may help the body manage stress and maintain balance. This powerful root has also been associated with promoting healthy energy levels, endurance, and supporting hormonal balance.

Schisandra Fruit

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Himalayan Goji

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Gotu Kola

The main group of components in gotu kola is the triterpenes including asiaticoside, madecassoside, asiatic acid, and madecassic acid, which have antioxidant and anti-inflammatory properties that are shown to positively influence brain plasticity which means a much sharper you.

  • Exhibits significant wound healing ability, Improves microcirculatory parameters, Sedative and anxiolytic properties, Antidepressant, Re-vitalize the brain and nervous system, increase attention span and concentration and combat aging: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116297/

Water Hyssop

Best known as a neural tonic and memory enhancer this powerful herb increases cerebral blood flow and neurotransmitter modulation.

Green Tea Extract

Healthy energy producer and one of the more researched and promising supplements. It upregulates fat metabolism at rest and during exercise. In recent years the consumption of Green Tea Extract has shown to help prevent lifestyle diseases like cardiovascular disease because of it’s preventative effects on chronic inflammation.

  • Helps with weight loss by increasing a protein hormone which is involved in regulating glucose levels as well
    as fatty acid breakdown:https://pubmed.ncbi.nlm.nih.gov/26093535/
  • Decrease cholesterol absorption and plasma levels, has strong free radical-scavenging
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Mikania Guaco

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Osha Root

A traditional Native American herb, Osha is also known as “Bear Root”. Native Americans noticed that when bears emerged from hibernation, the first thing they did after being in a state of torpor for 4 months was not feast on salmon or drink water, but rather, dig up osha and eat it. Why? It decongests and wakes up the lungs. Native Americans who used Osha were able to run further, and treat their colds and congestion. Modern research studies suggest Osha may support the immune system by offering protective effects against oxidative damage.

I want to thank you for your existence. I want you to know that functional medicine has changed my life, well the life of my autistic son. So much so that I plan on taking the Functional Medicine Health Coach Certificate and work with my new friend who is now a Functional Medicine Doctor from the Institute of Functional Medicine and spread the word on GI testing and how finding the underlying issues will help eliminate autistic traits. 

I hope to be able to meet you one day so I can share this great news with others. Changing my son’s diet has changed him. Food is medicine!! By the way, I’m cooking my rutabaga. I’m Italian and never grew up with these. With love.

Rita Mastrangelo

I found you on YouTube a couple of weeks ago and I’m hooked. I listen to you a couple of hours every morning. I am being tested for celiac disease and have been gluten-free for a couple of weeks. Thank you for all of your insight.

April Renee

Just wanted to tell you that you’re amazing! You are helping so many people all over the world! Including me! Thank you so very much, Dr. Tom O’Bryan!

Patricia Puddle

Good morning Dr. Tom, Would just like to say thank you! This time last year I was going through a hell of a time with my gut. Terrible indigestion on a regular basis, feeling as if I had eaten a boulder and the tiredness was doing my heed (scottish for head) in! With two young girls being tired is not an option!

I went to the doctors on a number of occasions and they decided to prescribe omeprazole to mask the problem, sorry help my problem. I decided taking these drugs was not an option for me! So I started googling the life out of it!! Low and behold you started popping up!! Oh and Gluten intolerance! 

Your advice has been second to none! You have in my case really simplified what gluten does to my body and now that I have cut it out (which as it appears in lots of foods, some I can’t understand) I have found that my symptoms very quickly reduced and now I’m a year down the line they have gone for the vast majority of the time!! For that I’m truly grateful. I now follow you on YouTube and Instagram, which continues to educate me and the importance of gut health. I look forward to your future advice. Yours faithfully,

Gary Christie

Black Ant Extract

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Siberian Ginseng

This well known adaptogen has been proven to reduce cardiovascular stress, lower and stabilize blood sugar to healthy levels, and encourages a more efficient lipid metabolism.

Pine Bark Extract

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Lion's Mane

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This is an enzyme/protein that speeds up biochemical reactions and helps to prevent and dissolve the formations of blood clots (thrombi); addresses the problem of blood hyperviscosity, thereby preventing thick and sticky blood, which is not conducive to overall cardiovascular health.


Referred to as the women’s ultimate power herb, by some herbal enthusiasts. Used in India for at least 3,000 years, Shatavari, is structurally similar to estrogen produced within the body. Some researchers have concluded shatavari can be a highly effective alternative to synthetic hormone replacement therapy for peri- and menopausal women.

Chaste Tree Berry

Improve female libido, mitigate PMS, reproductive health

Horny Goat Weed

Increase para-sympathetic nervous activity, mitigate osteoporosis, improve libido, enhance smooth muscle tissue function

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Bulgarian Tribulus

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Ginkgo Biloba

In recent decades, an extract of the leaves of the tree Ginkgo biloba L. has been used to improve memory in disorders like Dementia disorders that affect memory and intellectual functioning, and are caused primarily by Alzheimer’s disease and vascular disorders.

  • Potent antioxidant properties and ability to enhance peripheral and cerebral circulation, ginkgo’s primary application lies in the treatment of cerebrovascular dysfunctions and peripheral vascular disorders:https://pubmed.ncbi.nlm.nih.gov/11565403/
  • Experimental results showed extracts of G.Biloba to upregulate protein expressions of BDNF:
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Jiaogulan, a versatile herb, is celebrated for its potential to support overall well-being. Known for its adaptogenic properties, Jiaogulan may help the body cope with stress and maintain balance. This remarkable herb has also been associated with promoting healthy energy levels, boosting endurance, and fostering a sense of calm and relaxation.